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Kratom appears to have been used in Thailand for centuries, recreationally and as an anti-diarrhetic. Its use as an opiate substitute in Malaysia was reported in the nineteenth century. Peasants have used it to counteract the tedium of physical labor, similar to the use of coca in South America.

The chemistry of kratom alkaloids was investigated in the 1920s, and mitragynine was isolated in 1923. Kratom leaves became part of the ethnobotanical trade in the United States and Europe in mid 2000s. In the early 2000s, stories about the use of kratom to reduce opioid withdrawal effects began circulating on web forums.

Effects

Kratom is often described as producing simultaneous, contradictory effects. Users report both an opiate-like sedation and coca-like stimulation. The stimulating effects tend to predominate at low dose levels, which may aid in alertness and energy and cause mild euphoria. Higher doses tend to be more tranquilizing, causing an opiate-like dreamy reverie. However, excessive doses can cause severe nausea. Kratom is sometimes used as an opium substitute and has been found to suppress symptoms of opiate withdrawal.

When taken orally, Kratom effects typically become noticeable in 15-20 minutes and clearly apparent in 30-60 minutes. Strong doses may have a more rapid and dramatic onset. At the stimulant level the mind is more alert, physical energy and sometimes sexual energy is increased, ability to do hard monotonous physical work may be improved, one is more talkative, friendly, and sociable. Some people find this level edgy rather than pleasant.